个人简介

熊博，教授。2003年本科毕业于清华大学，2007年硕士毕业于清华大学，2013年博士毕业于美国贝勒医学院，2013-2015在美国华盛顿大学从事博士后研究工作，2016起在华中科技大学任教授，2023年起担任华中科技大学同济医学院法医学系系主任。

研究方向

主要研究方向为神经精神发育疾病的致病机制。通过比较大规模患者群体与正常人群的基因组序列及结构差异，筛选神经发育疾病潜在的致病基因与致病突变。构建斑马鱼、小鼠等动物模型，利用行为学，形态学，电生理，神经环路，多组学测序分析等方法研究候选基因的生物学功能，解析发病机制，并探索可能的干预方案。近年来，相关成果发表在Nature Genetics、PNAS、Nature Communications、Biological Psychiatry等杂志。

开设课程

法医物证学

法医学研究前沿

科研项目

1. 国家自然科学基金面上项目，81971084，WAC基因突变导致神经系统发育疾病的分子机制研究，2020年1月-2023年12月，55万元，主持

2. 自然科学基金委创新研究群体项目，81721005，神经精神药物药理，2018年1月-2023年12月，1050万元，骨干（负责子任务经费105万元）

3. 国家自然科学基金面上项目，81671118，GIGYF1和GIGYF2基因突变引起小儿自闭症的致病机理研究，2017年1月-2020年12月，85万，主持

4. 华中科技大学同济医学院重大疾病研究交叉创新团队资助计划，精神分裂症的精神分裂症的多维组学与分子机理研究，2016年1月-2018年12月，45万元，已结题，主持，

5. 中组部海外高层次青年人才引进项目，第十一批，200万元，遗传学方向

论文专著与专利

1. Weicheng Duan, Guiyang Huang, Yang Sui, Kang Wang, Yuxin Yu, Xufeng Chu， Xu Cao, Liangpei Chen, Jiahui Liu, Evan E. Eichler, Bo Xiong. Deficiency of DDX3X results in neurogenesis defects and abnormal behaviors via dysfunction of the Notch signaling, PNAS, 2024 Nov 5;121(45):e2404173121. doi: 10.1073/pnas.2404173121

2. Jing Wang, Xinyao Meng, Xuyong Chen, Jun Xiao, Xiaosi Yu, Luyao Wu, Zejian Li, Ke Chen, Xuan Zhang, Bo Xiong*, Jiexiong Feng*. Cinchophen induces RPA1 related DNA damage and apoptosis to impair ENS development of zebrafish. Ecotoxicol Environ Saf. 2024 Mar 1:272:116032.

3. Zijiao Ding, Guiyang Huang, Tianyun Wang, Weicheng Duan, Hua Li, Yirong Wang, Huiting Jia, Ziqian Yang, Kang Wang, Xufeng Chu, Evangeline C Kurtz-Nelson, Kaitlyn Ahlers, Rachel K Earl, Yunyun Han, Pamela Feliciano, Wendy K Chung, Evan E Eichler, Man Jiang*, Bo Xiong*. Genetic Ablation of GIGYF1, Associated With Autism, Causes Behavioral and Neurodevelopmental Defects in Zebrafish and Mice. Biol Psychiatry. 2023 Nov 15;94(10):769-779.

4. Kang Wang, Yuxin Yu, Yinhui Xu, Yingzi Yue, Fang Zhao, Wenyang Feng, Yijie Duan, Weicheng Duan, Jingjing Yue, Zhiyun Liao, Peng Fei, Hui Sun*, Bo Xiong*. TSA-PACT: a method for tissue clearing and immunofluorescence staining on zebrafish brain with improved sensitivity, specificity and stability. Cell Biosci. 2023 May 26;13(1):97. doi: 10.1186/s13578-023-01043-1.

5. Fei Long, Jing Zheng, Jiayi Zhou, Ping Hu*, Bo Xiong*. Knockout of tanc2 causes autism-like behavior and sleep disturbance in zebrafish. Autism Res. 2023 Mar;16(3):524-534.

6. Jing Wang, Xinyao Meng, Chenzhao Feng, Jun Xiao, Xiang Zhao, Bo Xiong*, Jiexiong Feng*. Benzophenone-3 induced abnormal development of enteric nervous system in zebrafish through MAPK/ERK signaling pathway. Chemosphere. 2021 Oct;280:130670. doi: 10.1016/j.chemosphere.2021.130670

7. Holly AF Stessman^#, Bo Xiong^#, Bradley P Coe1, Tianyun Wang, Kendra Hoekzema, Michaela Fenckova, Malin Kvarnung, Jennifer Gerdts, Sandy Trinh, Nele Cosemans, Laura Vives, Janice Lin, Tychele N Turner, Gijs Santen, Claudia Ruivenkamp, Marjolein Kriek, Arie van Haeringen, Emmelien Aten, Kathryn Friend, Jan Liebelt, Christopher Barnett, Eric Haan, Marie Shaw, Jozef Gecz, Britt-Marie Anderlid, Ann Nordgren, Anna Lindstrand, Charles Schwartz, R Frank Kooy, Geert Vandeweyer, Celine Helsmoortel, Corrado Romano, Antonino Alberti, Mirella Vinci, Emanuela Avola, Stefania Giusto, Eric Courchesne, Tiziano Pramparo, Karen Pierce, Srinivasa Nalabolu, David G Amaral, Ingrid E Scheffer, Martin B Delatycki, Paul J Lockhart, Fereydoun Hormozdiari, Benjamin Harich, Anna Castells-Nobau, Kun Xia, Hilde Peeters, Magnus Nordenskjöld, Annette Schenck, Raphael A Bernier, Evan E Eichler. Targeted sequencing identifies 91 neurodevelopmental-disorder risk genes with autism and developmental-disability biases. Nature Genetics. 2017 Apr;49(4):515-526

8. Tianyun Wang^#，Hui Guo^#，Bo Xiong^#，Holly A.F. Stessman^#，Huidan Wu，Bradley P. Coe，Tychele N. Turner，Yanling Liu，Wenjing Zhao，Kendra Hoekzema，Laura Vives，Lu Xia，Meina Tang，Jianjun Ou，Biyuan Chen，Yidong Shen，Guanglei Xun，Min Long，Janice Lin，Zev N. Kronenberg，Yu Peng，Ting Bai，Honghui Li，Xiaoyan Ke，Zhengmao Hu，Jingping Zhao，Xiaobing Zou，Kun Xia^*, & Evan E. Eichler^*,，De novo genic mutations among a Chinese autism spectrum disorder cohort. Nature Communications, 2016; 7: 13316.

9. Raphael Bernier^#, Christelle Golzio^#, Bo Xiong^#, Holly A. Stessman^#, Bradley P. Coe^#, Osnat Penn, Kali Witherspoon, Jennifer Gerdts, Carl Baker, Anneke T. Vulto-van Silfhout, Janneke H. Schuurs-Hoeijmakers, Marco Fichera, Paolo Bosco, Serafino Buono, Antonino Alberti, Pinella Failla, Hilde Peeters, Jean Steyaert, Lisenka E.L.M. Vissers, Ludmila Francescatto, Heather C. Mefford, Jill A. Rosenfeld, Trygve Bakken, Brian J. O’Roak, Matthew Pawlus, Randall Moon, Jay Shendure, David G. Amaral, Ed Lein, Julia Rankin, Corrado Romano, Bert B.A. de Vries, Nicholas Katsanis, Evan E. Eichler. Disruptive CHD8 mutations define a subtype of autism early in development. Cell, 2014, Jul 17;158(2):263-76

10. Bo Xiong, Hugo J. Bellen. Rhodopsin homeostasis and retinal degeneration: lessons from the fly. Trends in Neurosciences, 2013, 36(11):652-60

11. Bo Xiong, Vafa Bayat, Manish Jaiswal, Ke Zhang, Hector Sandoval, Wu-Lin Charng, Tongchao Li, Gabriela David, Lita Duraine, Yong-Qi Lin, G. Gregory Neely, Shinya Yamamoto, Hugo J. Bellen. Crag is a GEF for Rab11 required for Rhodopsin trafficking and maintenance of adult photoreceptor cells. PLoS Biology, 2012, 10:e1001438

12. Bo Xiong^#, Yanning Rui^#, Min Zhang, Kehui Shi, Shunji Jia, Tian Tian, Kun Yin, Huizhe Huang, Shuyong Lin, Xingang Zhao, Yinghua Chen, Ye-Guang Chen , Sheng-Cai Lin^*, Anming Meng^*. Tob1 controls dorsal development of zebrafish embryos by antagonizing maternal beta-catenin transcriptional activity. Developmental Cell, 2006, 11:225-238

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