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熊博

2016/03/12 14:16:24 点击数:

姓名

熊博

性别

出生年月

1982.4

电话

027-83692642

职务

职称

教授

传真

E-mail

bxiong@hust.edu.cn

工作单位

华中科技大学同济医学院法医学系

学习经历

1999.09 - 2003.07 清华大学生物科学与技术系,获学士学位;

2003.09 - 2007.01 清华大学生物科学与技术系,获硕士学位

2007.06 - 2013.07 美国贝勒医学院(Baylor College of Medicine);获博士学位

工作经历

2013.10 - 2015.12,美国华盛顿大学(University of  Washington)博士后

2016.01至今  华中科技大学同济医学院法医学系教授;

社会兼职

主讲课程

法医遗传学,法医物证学

研究方向

法医遗传学,医学遗传学,神经类疾病的分子分型及动物模型

主要著作

主要论文

第一作者文章(#为并列第一作者):

Bernier, R.#, Golzio, C.#, Xiong,  B.#, Stessman, H.A.#, Coe, B.P.#, Penn, O., Witherspoon, K., Gerdts, J.,  Baker, C., Vulto-van Silfhout, A.T., et al. (2014). Disruptive CHD8 mutations  define a subtype of autism early in development. Cell 158, 263-276.

Xiong, B., and Bellen,  H.J. (2013). Rhodopsin homeostasis and retinal degeneration: lessons from the  fly. Trends in neurosciences 36,  652-660

Xiong, B., Bayat, V.,  Jaiswal, M., Zhang, K., Sandoval, H., Charng, W.L., Li, T., David, G.,  Duraine, L., Lin, Y.Q., et al. (2012). Crag is a GEF for Rab11 required for  rhodopsin trafficking and maintenance of adult photoreceptor cells. PLoS biology 10, e1001438

Rui, Y.#, Xu, Z.#, Xiong, B.#,  Cao, Y.#, Lin, S., Zhang, M., Chan, S.C., Luo, W., Han, Y., Lu, Z., et al.  (2007). A beta-catenin-independent dorsalization pathway activated by  Axin/JNK signaling and antagonized by aida. Developmental cell 13, 268-282

Xiong, B.#, Rui, Y.#,  Zhang, M., Shi, K., Jia, S., Tian, T., Yin, K., Huang, H., Lin, S., Zhao, X.,  et al. (2006). Tob1 controls dorsal development of zebrafish embryos by  antagonizing maternal beta-catenin transcriptional activity. Developmental cell 11, 225-238

其它作者文章(节选):

Stessman Holly, Willemsen Marjolein, Fenckova Michaela, Penn Osnat,  Hoischen Alexander, Xiong Bo, Wang  Tianyun, Hoekzema Kendra, Vives Laura, Vogel Ida, et al., Disruption of POGZ  Is Associated with Intellectual Disability and Autism Spectrum Disorders. The American Journal of Human Genetics,  2016, 98(3): 541-552.

David-Morrison G, Xu Z, Rui YN, Charng WL, Jaiswal M, Yamamoto S, Xiong B, Zhang K, Sandoval H, Duraine  L, Zuo Z, Zhang S, Bellen HJ. WAC regulates mTOR activity by by acting as an  adaptor for the TTT and Pontin/Reptin complexes. Developmental Cell, 2016, 36:139-151

Jaiswal M, Haelterman NA, Sandoval H, Xiong B, Donti T, Kalsotra A, Yamamoto S, Cooper TA, Graham BH, Bellen  HJ. Impaired mitochondrial energy production causes light induced  photoreceptor degeneration independent of oxidative stress. PLoS Biology, 2015, 13: e100219

Haelterman NA, Jiang L, Li Y, Bayat V, Sandoval H, Ugur B, Tan KL,  Zhang K, Bei D, Xiong B, Charng  WL, Busby T, Jawaid A, David G, Jaiswal M, Venken KJT, Yamamoto S, Chen R,  Bellen HJ. Large-scale identification of chemically induced mutations in  Drosophila melanogaster. Genome  Research, 2014, 24:1707-1718

Wang, S., Tan, K.L., Agosto, M.A., Xiong, B., Yamamoto, S., Sandoval, H., Jaiswal, M., Bayat, V.,  Zhang, K., Charng, W.L., et al. (2015). Correction: the retromer complex is  required for rhodopsin recycling and its loss leads to photoreceptor  degeneration. PLoS biology 13,  e1002170.

Yamamoto, S., Jaiswal, M., Charng, W.L., Gambin, T., Karaca, E.,  Mirzaa, G., Wiszniewski, W., Sandoval, H., Haelterman, N.A., Xiong, B., et al. (2014). A  drosophila genetic resource of mutants to study mechanisms underlying human  genetic diseases. Cell 159,  200-214.

Yamamoto, S., Charng, W.L., Rana, N.A., Kakuda, S., Jaiswal, M.,  Bayat, V., Xiong, B., Zhang, K.,  Sandoval, H., David, G., et al. (2012). A mutation in EGF repeat-8 of Notch  discriminates between Serrate/Jagged and Delta family ligands. Science 338, 1229-1232.

科研项目

2015年,“千人计划”青年学者项目,第十一批,经费:200万元,项目时间:2016.01-2018.12

2016年,华中科技大学人才引进专项经费:200万元,项目时间:2016.01-2021.12

表彰奖励

2007年获清华大学研究生奖学金一等奖

2010年获Burroughs Wellcome基金会“疾病的大规模人群研究与实验室基础研究交叉培养“项目两年的博士生奖学金资助

2015年获“千人计划”青年学者项目第十一批资助

 


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